Gut health and inflammation · Peptide Therapy
KPV Peptide in Tampa, FL
KPV is a tiny three-amino-acid peptide that may calm inflammation in the gut and skin and support the intestinal barrier. At Padgett it is an oral capsule, prescribed after a free consultation with a licensed provider.
Padgett Medical Center in Tampa, Florida offers BPC-157, TB-500, KPV, MOTS-c, Semax and Epitalon, prescribed after a free consultation with a licensed provider and compounded by a licensed U.S. compounding pharmacy.
- The consultation is free. You only pay for your peptides if you start.
- New patients: 10% off the first peptide order when you book online with a card on file
- In person in Tampa or telehealth anywhere in Florida
KPV at Padgett
From $90
Every product and price is listed below.
- Consultation
- Free
- Form
- An oral capsule
- Prescribed by
- A licensed provider
- Compounded by
- A licensed U.S. compounding pharmacy
Compounded peptides have not been approved by the FDA.
Pricing
KPV price in Tampa
The consultation is free. You only pay for your peptides if you start. KPV at Padgett Medical Center in Tampa costs $90 (capsule, 125 mcg, 30 capsules), $150 (capsule, 250 mcg, 30 capsules) or $240 (capsule, 500 mcg, 30 capsules).
| Product | Order | Price | Card on file10% off first order, new patients |
|---|---|---|---|
| Capsule125 mcg | 30 capsules | $90 | $81 |
| Capsule250 mcg | 30 capsules | $150 | $135 |
| Capsule500 mcg | 30 capsules | $240 | $216 |
New patients who book online with a card on file get 10% off their first peptide order ($90 becomes $81). Nothing is charged when you book, and current patients pay the listed price.
Your provider confirms the right product at your consultation. Prices are subject to change. Compounded for you by a licensed U.S. compounding pharmacy: about our partner pharmacies.
Compounded peptides have not been approved by the FDA.
What is KPV?
KPV is a very small peptide made of just three amino acids: lysine (K), proline (P) and valine (V), which is where its name comes from. It is the tail end (amino acids 11 to 13) of alpha-melanocyte-stimulating hormone (alpha-MSH), a natural hormone that helps regulate inflammation and skin pigment.
Researchers became interested in KPV because it appears to keep alpha-MSH's anti-inflammatory activity without its skin-darkening effect. Lab research shows KPV does not act on the melanocortin receptor that drives tanning, though no human study has confirmed this.
Who KPV may help
KPV may help with:
- Inflammation in the gut
- The intestinal barrier (the gut lining)
- Immune regulation
- Skin inflammation and whole-body inflammation
People also ask about KPV for IBS, leaky gut, inflammatory bowel disease and mast cell activation syndrome. KPV may help calm the inflammation behind some of these, but it has not been tested in people with any of them, and it does not replace treatment from your GI specialist or other doctors.
How KPV may work
In lab studies, KPV calms inflammatory signaling inside cells. It blocks activation of NF-kappaB and MAP kinase, two main switches that turn on inflammation, and it lowers the release of inflammatory cytokines.
In the gut, a transporter called PepT1 carries KPV into intestinal lining cells and immune cells. PepT1 normally absorbs small protein fragments from food. It is found mainly in the small intestine, but it increases in the colon during inflammation, which may help KPV reach inflamed areas. KPV's exact molecular target is still unknown.
What the research shows
What has been seen in cells and animals, what has been seen in people, and what has not been shown yet.
Lab and animal studies
Almost all KPV research is in cells and mice. In human intestinal and immune cells, very small amounts of KPV lowered inflammatory signaling (Gastroenterology, 2008). In two mouse models of chemically induced colitis, KPV in drinking water reduced inflammation and inflammatory markers, and mice with colitis given KPV regained weight faster and had less colon inflammation (Inflammatory Bowel Diseases, 2008).
Later mouse studies packaged KPV in nanoparticles or gels to target the colon and also saw less colitis. Research on the parent hormone, alpha-MSH, covers skin inflammation, wound healing, arthritis and eye inflammation in animal models.
Studies in people
No clinical trials of KPV in people have been published, by mouth or any other route. In 2026, FDA reviewers found no human studies, no human safety data and no human data on how KPV is absorbed. A 2023 review of melanocortin-based approaches to inflammatory bowel disease described human experience as mainly anecdotal, and a search of the medical literature found no studies of KPV in IBS, leaky gut or mast cell activation syndrome.
The bottom line
Lab and mouse research suggests KPV may calm gut and skin inflammation and support the intestinal lining. No clinical trials have tested its effects in people.
KPV is not FDA-approved. FDA's 2026 review covered KPV as a topical cream or gel, not as an oral capsule. In July 2026 an FDA advisory committee voted 8 to 6, with 1 abstention, to recommend adding KPV to the list of substances pharmacies may use in compounding. FDA staff had recommended against it. The vote is advisory.
How KPV is taken
At Padgett, KPV comes as an oral capsule. Your provider sets the dose; the general pattern for each product is below.
- Capsule, 125 mcg30 capsules. 1 capsule a day.
- Capsule, 250 mcg30 capsules. 1 capsule a day.
- Capsule, 500 mcg30 capsules. 1 capsule a day.
The HHS interim policy covers compounded KPV only by mouth or on the skin, not by injection, and for forms taken by mouth it also requires the compounding pharmacy to document adequate absorption in people. KPV is small enough for PepT1, the gut's transporter for small protein fragments, to carry it into intestinal cells, and in mice KPV given in drinking water reduced colon inflammation. No published study has measured how much oral KPV people absorb.
Your provider picks the capsule strength and sets your dose at your consultation.
KPV side effects and safety
Your provider reviews your health history and every medicine you take before prescribing.
Possible side effects
- Nausea
- Stomach discomfort
- Headaches
- Allergic reactions
- Long-term effects on immune signaling are not yet known
Tell your provider about any new symptom, or call (813) 888-7710. In a medical emergency, call 911.
Who should not take KPV
- People who are pregnant, trying to become pregnant, or breastfeeding (no human data and no reproductive studies)
- Children and teens under 18 (not studied)
- Anyone who has had an allergic reaction to KPV or any ingredient in the capsule
- People with Crohn's disease, ulcerative colitis or another diagnosed inflammatory condition who would use KPV in place of their prescribed medicines (KPV has not been tested in people and is not a substitute)
- People with a weakened immune system or who take immune-suppressing medicines, unless their provider and specialist agree (its effects on immune signaling in people are unknown)
This is not a complete list. Your provider reviews your full health history before prescribing.
What is known about safety
Because KPV has not been studied in people, its side effects in people are unknown. FDA's adverse event database had no KPV reports through December 2025. That does not show it is safe, because FDA says pharmacies that compound medicines generally do not report adverse events. No animal toxicity, genetic toxicity, reproductive or cancer studies of KPV have been published.
FDA notes that peptides can trigger immune responses, and that impurities or clumping can raise that risk. KPV acts on inflammatory pathways, and its long-term effects on immune signaling in people are unknown. No published study has measured how much oral KPV reaches the body or the colon in people.
Medicines and interactions
No drug interaction studies of KPV exist. Because KPV acts on immune and inflammatory signaling, tell your provider if you take medicines that affect the immune system, such as steroids, biologics or other immune-suppressing drugs for IBD, arthritis or psoriasis. This concern is theoretical, not something that has been observed. If you see a GI specialist, keep them informed, and tell your provider about every medicine and supplement you take.
Peptide quality
Prescribed and pharmacy-compounded, not "research grade"
At Padgett Medical Center in Tampa, peptides are prescribed only after a consultation with a licensed medical provider, and each one is compounded for the individual patient by a licensed U.S. compounding pharmacy. That is not the same as the "research grade" or "research use only" peptides sold online, which are labeled not for human use and are not made or checked to pharmacy standards for people, so there is no way to be sure of their strength, purity or sterility, or how well they will work.
| Prescribed and pharmacy-compounded at Padgett | Research-grade / research use only |
|---|---|
| Who decides it's right for you | |
| A licensed provider reviews your health history at a free consultation before anything is prescribed. | No one. You pick a vial from a website. |
| Where it's made | |
| A licensed U.S. compounding pharmacy, made for you to a prescription. | Unknown manufacturers, often overseas, selling "for research use only". |
| Meant for people? | |
| Yes. Compounded for a named patient to take. | No. Labeled not for human use or consumption. |
| Strength, purity and sterility | |
| Held to pharmacy compounding standards. | Not verified to pharmacy standards, so the dose and what else is in the vial are unknown. |
| Support while you take it | |
| Tell your provider about any side effect or question while you take it; they can adjust your plan. | You're on your own. |
| Price | |
| Published on every peptide page, and the consultation is free. | Cheap per vial, but you can't know what you're paying for. |
Regulatory status
Are these peptides FDA-approved? Where things stand in November 2026
No. BPC-157, TB-500, KPV, MOTS-c, Semax and Epitalon are not FDA-approved, and compounded medications are not FDA-approved. The FDA does not review compounded drugs for safety, effectiveness or quality before they are prescribed.
On October 30, 2026, the U.S. Department of Health and Human Services (HHS) published a notice in the Federal Register about an interim policy for compounding these six peptides. It says HHS does not intend to take enforcement action against state-licensed pharmacies and licensed physicians that compound them for individual patients while the FDA completes formal rulemaking, as long as specific conditions are met. Those conditions include:
- A prescription for each patient
- A bulk ingredient from an FDA-registered manufacturer, tested for identity, purity, strength and contaminants
- One peptide per product, so no blends
- Only the forms the policy lists for each peptide (for example, Semax only as a nasal spray)
- For forms taken by mouth, documentation that enough of the peptide is absorbed in people
- Reporting serious side effects to the FDA
The policy is temporary and may change. The Federal Register notice announced it as a draft, open for public comment into mid-November 2026, so HHS may revise it, and HHS has said it may revisit it if safety or quality problems come up. The policy does not mean these peptides are proven safe or effective. It does not cover peptides sold as research chemicals or supplements.
Before it, in July 2026, an FDA advisory committee voted to recommend adding these six peptides to the list of substances pharmacies may compound from. FDA staff had recommended against it, citing limited human safety data, and the vote is advisory.
At Padgett Medical Center, peptides are prescribed only after a consultation with a licensed provider, and each one is compounded for you by a licensed U.S. compounding pharmacy.
Sources: Federal Register: notice of the HHS interim policy on 503A compounding of certain peptides, 91 FR 68526 (October 30, 2026), FR Doc. 2026-22192; Holland & Knight: HHS issues interim enforcement discretion policy for compounding of 6 peptides (November 4, 2026); FDA: Certain bulk drug substances for use in compounding that may present significant safety risks (content current April 22, 2026); Healio: FDA committee recommends looser restrictions for several peptides (July 24, 2026).
KPV questions, answered
What is KPV peptide?
KPV is a very small peptide made of three amino acids: lysine, proline and valine. It is a fragment of alpha-MSH, a natural hormone that helps regulate inflammation. Lab and mouse research suggests KPV may calm inflammation in the gut and skin and may support the intestinal lining.
Has KPV been tested in people?
No clinical trials of KPV in people have been published. In 2026, FDA reviewers found no human studies or human safety data for KPV by any route. The evidence so far comes from cell studies and mouse models of colitis, where KPV reduced inflammation.
Is KPV FDA-approved?
No. KPV is not FDA-approved for any use, and compounded peptides are not FDA-approved drugs. At Padgett, a licensed provider reviews your health history at a free consultation before anything is prescribed, and a licensed U.S. compounding pharmacy compounds it for you.
Is KPV legal in Florida?
KPV is not FDA-approved, so the answer depends on how it is made and prescribed. On October 30, 2026, the U.S. Department of Health and Human Services (HHS) published a notice in the Federal Register about an interim policy for KPV and five other peptides. It says HHS does not intend to take enforcement action against state-licensed pharmacies and licensed physicians that compound them for individual patients while the FDA completes formal rulemaking, as long as conditions are met, including a prescription for each patient, a tested ingredient from an FDA-registered manufacturer and one peptide per product. For KPV, the policy covers only forms taken by mouth or applied to the skin, and a form taken by mouth also needs documented absorption in people; KPV at Padgett is an oral capsule. The policy does not cover products sold online as "research use only". It is temporary and may change, and Florida pharmacy and medical rules still apply. At Padgett Medical Center, KPV is prescribed after a consultation with a licensed provider and compounded by a licensed U.S. compounding pharmacy.
Where can I get KPV in Tampa?
At Padgett Medical Center, 6904 W. Linebaugh Ave, Tampa, FL 33625. You start with a free consultation with a licensed provider, in person at our Tampa clinic or by telehealth from anywhere in Florida. If KPV is right for you, a licensed U.S. compounding pharmacy compounds it for you, and you only pay for it if you start.
Oral KPV vs injectable KPV: why a capsule?
The HHS interim policy covers compounded KPV only by mouth or on the skin, and for forms taken by mouth it requires the compounding pharmacy to document adequate absorption in people. KPV at Padgett is an oral capsule. KPV is small enough for PepT1, a transporter the gut uses to absorb small protein fragments from food, to carry it into intestinal cells, and PepT1 increases in the colon during inflammation. In mice, KPV given in drinking water reduced colon inflammation. No published study has measured how much oral KPV people absorb or whether it acts the same way in people.
What are the side effects of KPV?
KPV's side effects in people have not been studied. FDA had no adverse event reports for KPV through 2025, but that does not prove it is safe, because pharmacies that compound medicines generally do not report side effects to FDA. Possible effects include stomach upset, nausea, headache or an allergic reaction. Long-term effects on the immune system are unknown, so tell your provider about any new symptom.
Can I use KPV if I have Crohn's disease or ulcerative colitis?
KPV does not replace your IBD medicines. Mouse studies of colitis are the main reason KPV is studied for the gut, but it has not been tested in people with IBD. Do not stop any prescribed medicine to try KPV. Talk with your GI specialist and your provider together first.
How is Padgett's KPV different from "research grade" KPV sold online?
"Research grade" or "research use only" KPV is labeled not for human use. It is not made or checked to pharmacy standards for people, so its strength, purity and sterility are unknown. Injectable KPV sold online falls outside the HHS interim policy, which covers KPV only by mouth or on the skin. At Padgett, KPV is prescribed only after a consultation with a licensed provider, and a licensed U.S. compounding pharmacy compounds it for you. Research-grade vs pharmacy-compounded peptides explains the difference.
How much does KPV cost per month?
The consultation is free, and nothing is charged when you book. You only pay for KPV if you start it. KPV at Padgett Medical Center in Tampa costs $90 (capsule, 125 mcg, 30 capsules), $150 (capsule, 250 mcg, 30 capsules) or $240 (capsule, 500 mcg, 30 capsules). New patients who book online with a card on file get 10% off their first peptide order ($90 becomes $81). Nothing is charged when you book, and current patients pay the listed price. Each order is 30 capsules, and the general pattern is 1 capsule a day; your provider sets your dose.
Other peptides we offer
Each is prescribed after the same free consultation. You can ask about more than one.
- Recovery and healingBPC-157Also called Body Protection Compound-157, BPC 157May support healing of tendons, ligaments and injuries, and the gut lining.From $275BPC-157 in Tampa
- Recovery and healingTB-500Also called Thymosin Beta-4 fragment, TB500May support tissue repair, wound healing and muscle recovery.From $300TB-500 in Tampa
- Metabolism and energyMOTS-cAlso called MOTS-C, MOTScMay support insulin sensitivity, metabolism and exercise endurance.From $400MOTS-c in Tampa
- Focus and cognitionSemaxAlso called Semax nasal spray, Semax peptideMay support focus, memory and mental clarity, and ease brain fog.From $125Semax in Tampa
- Sleep and healthy agingEpitalonAlso called Epithalon, EpitaloneMay support sleep quality and healthy cellular aging.From $250Epitalon in Tampa
Peptide guides
KPV and peptide therapy near you
Sources
- Dalmasso G, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology, 2008 (PMC2431115)
- Kannengiesser K, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflammatory Bowel Diseases, 2008 (PMID 18092346)
- Brzoska T, et al. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects. Endocrine Reviews, 2008 (PMID 18612139)
- Gravina AG, et al. The melanocortin system in inflammatory bowel diseases. Cells, 2023 (PMC10378568)
- FDA briefing document: KPV-related bulk drug substances, Pharmacy Compounding Advisory Committee, July 23-24, 2026
- Healio: FDA committee recommends looser restrictions for several peptides (July 24, 2026)
- Federal Register: notice of the HHS interim policy on 503A compounding of certain peptides, 91 FR 68526 (October 30, 2026), FR Doc. 2026-22192
Free peptide consultation
Talk with a licensed provider about KPV
The consultation is free. You only pay for your peptides if you start. In person at our Tampa clinic or by telehealth anywhere in Florida, and new patients who book online with a card on file get 10% off their first peptide order.
Interested in more than one peptide? Pick them all when you book.
* Compounded peptides have not been approved by the FDA. They have not been reviewed by the FDA for safety, effectiveness or quality, and none of the peptides on this site is an FDA-approved drug. The benefits described are possibilities from research, not promises, and results vary from person to person. A licensed provider decides at your consultation whether a peptide is right for you. This page is educational and is not medical advice.
