Metabolism and energy ยท Peptide Therapy
MOTS-c Peptide in Tampa, FL
MOTS-c is a peptide your body makes in its mitochondria. In animal studies it may support insulin sensitivity, metabolism and exercise endurance. Human evidence is still very limited, so a licensed provider goes over what is known before anything is prescribed.
Padgett Medical Center in Tampa, Florida offers BPC-157, TB-500, KPV, MOTS-c, Semax and Epitalon, prescribed after a free consultation with a licensed provider and compounded by a licensed U.S. compounding pharmacy.
- The consultation is free. You only pay for your peptides if you start.
- New patients: 10% off the first peptide order when you book online with a card on file
- In person in Tampa or telehealth anywhere in Florida
MOTS-c at Padgett
From $400
Every product and price is listed below.
- Consultation
- Free
- Form
- An injection
- Prescribed by
- A licensed provider
- Compounded by
- A licensed U.S. compounding pharmacy
Compounded peptides have not been approved by the FDA.
Pricing
MOTS-c price in Tampa
The consultation is free. You only pay for your peptides if you start. MOTS-c at Padgett Medical Center in Tampa costs $400 (injection, 10 mg in a 2 mL vial, 4 vials).
| Product | Order | Price | Card on file10% off first order, new patients |
|---|---|---|---|
| Injection10 mg in a 2 mL vial | 4 vials | $400 | $360 |
New patients who book online with a card on file get 10% off their first peptide order ($400 becomes $360). Nothing is charged when you book, and current patients pay the listed price.
Your provider confirms the right product at your consultation. Prices are subject to change. Compounded for you by a licensed U.S. compounding pharmacy: about our partner pharmacies.
Compounded peptides have not been approved by the FDA.
What is MOTS-c?
MOTS-c (also written MOTSc or MOTS c; short for mitochondrial open reading frame of the 12S rRNA type-c) is a small peptide, a chain of 16 amino acids, that the human body makes on its own. Most proteins are coded in the DNA in the cell's nucleus. MOTS-c is unusual because its code sits in the separate DNA inside mitochondria, the parts of the cell that produce energy.
Researchers first described it in 2015. It is found in skeletal muscle, heart and brain tissue, and it circulates in the blood. The MOTS-c used as a medication is a lab-made copy of the same 16-amino-acid sequence. It is not an FDA-approved drug.
Who MOTS-c may help
MOTS-c may help with:
- Insulin sensitivity
- Exercise endurance
- Inflammation
- Healthy cellular aging
These effects come from cell and animal studies and have not been established in people. MOTS-c does not replace exercise, and it is not a substitute for diabetes care or for tested weight-loss medicines.
How MOTS-c may work
In cell and animal studies, MOTS-c acts mainly on skeletal muscle. It appears to slow the folate cycle, a pathway cells use to build DNA. That lets a natural molecule called AICAR build up, and AICAR switches on AMPK, an energy-sensing enzyme that helps cells take in glucose and burn fat for fuel. Exercise also switches on AMPK, which is why MOTS-c is sometimes called an exercise mimetic.
Under stress, such as exercise or a lack of nutrients, MOTS-c can also move into the cell nucleus and change the activity of genes involved in stress response and metabolism. These mechanisms are not fully worked out: FDA noted in 2026 that its exact molecular target is unknown, and that a lab study found MOTS-c breaks down quickly in human blood.
What the research shows
What has been seen in cells and animals, what has been seen in people, and what has not been shown yet.
Lab and animal studies
In the 2015 discovery study, mice fed a high-fat diet and given daily MOTS-c injections gained less weight than untreated mice (about 20% lighter after 8 weeks) and had less insulin resistance. MOTS-c also restored insulin sensitivity in the muscle of older mice. In a 2021 study, MOTS-c improved treadmill performance in young, middle-aged and old mice, and started late in life it improved physical capacity and modestly extended lifespan in old male mice.
Not every result is favorable. A 2026 study in fat-derived stem cells from people with obesity found that MOTS-c switched on energy signaling but also raised markers of cell aging and inflammation.
Studies in people
Most human research measures the body's own MOTS-c rather than giving it as a drug. In 10 sedentary, healthy young men, MOTS-c in muscle rose sharply after a stationary-bike session. Blood levels tend to be lower in older adults, and studies of people with obesity and type 2 diabetes have found mixed results.
A modified version of MOTS-c (CB4211) completed an early-stage, placebo-controlled safety trial in 2021, but no results are posted. In its 2026 review, FDA said it found no published clinical studies of MOTS-c given to humans by any route.
The bottom line
Cell and animal research suggests MOTS-c may support insulin sensitivity, metabolism and exercise capacity. These benefits have not been established in people.
MOTS-c is not FDA-approved. For the July 2026 advisory committee meeting, FDA staff recommended against adding MOTS-c to the list of substances pharmacies may compound, citing the lack of human safety and effectiveness data. The committee voted to recommend adding it anyway. The vote is advisory.
How MOTS-c is taken
At Padgett, MOTS-c comes as an injection. Your provider sets the dose; the general pattern for each product is below.
- Injection, 10 mg in a 2 mL vial4 vials. Twice a week.
MOTS-c is given as a small injection under the skin. Your provider sets the dose and schedule and, if you take a glucose-lowering medicine, may ask you to check your blood sugar more often at first.
MOTS-c side effects and safety
Your provider reviews your health history and every medicine you take before prescribing.
Possible side effects
- Nausea
- Headaches
- Fatigue
- Dizziness
- Low blood sugar
- Anxiety
- Injection site reaction
- Insomnia (rare)
Tell your provider about any new symptom, or call (813) 888-7710. In a medical emergency, call 911.
Who should not take MOTS-c
- People who are pregnant or trying to become pregnant (there are no reproductive or developmental safety studies)
- People who are breastfeeding (no data on whether MOTS-c passes into breast milk)
- Anyone under 18 (not studied in children or teens)
- People with active cancer or in cancer treatment, unless their oncologist agrees (MOTS-c's role in tumor biology is unclear)
- People prone to low blood sugar, or taking insulin or a sulfonylurea, unless the provider sets up close glucose monitoring
- Competitive athletes subject to drug testing (MOTS-c is prohibited under World Anti-Doping Agency rules)
- Anyone who has had an allergic reaction to MOTS-c or another injected peptide
This is not a complete list. Your provider reviews your full health history before prescribing.
What is known about safety
Because MOTS-c has not been studied in published human trials, its side effects in people are not well documented. The side effects listed here are plausible, but no controlled study has measured how often they happen. Low blood sugar is a plausible risk: MOTS-c lowered blood glucose by about half in obese mice, and it acts on glucose-uptake pathways in muscle.
FDA's 2026 review found no toxicity, genotoxicity, reproductive or cancer studies, and no human data on how the body absorbs and clears it, and concluded that the potential safety risks in humans are unknown. FDA also raised immunogenicity: an injected peptide can lead the immune system to make antibodies against it, with effects ranging from none, to loss of effect, to rare serious allergic reactions. Clumping and impurities raise this risk.
Findings on cancer are early and mixed. MOTS-c slowed ovarian cancer cell growth in lab and mouse studies, while in one observational study people with lung cancer had higher blood MOTS-c than controls. No study has tested whether taking MOTS-c changes cancer risk.
Medicines and interactions
No formal drug interaction studies exist for MOTS-c. Because it may lower blood glucose, combining it with diabetes and glucose-lowering medicines (insulin, sulfonylureas such as glipizide, glyburide or glimepiride, metformin, or GLP-1 or GLP-1/GIP medicines such as semaglutide or tirzepatide) could raise the chance of low blood sugar. MOTS-c works through AMPK, the same energy-sensing pathway metformin is thought to act on.
No combination with other peptides or supplements has been studied. Give your provider a full list of your medicines and supplements.
Peptide quality
Prescribed and pharmacy-compounded, not "research grade"
At Padgett Medical Center in Tampa, peptides are prescribed only after a consultation with a licensed medical provider, and each one is compounded for the individual patient by a licensed U.S. compounding pharmacy. That is not the same as the "research grade" or "research use only" peptides sold online, which are labeled not for human use and are not made or checked to pharmacy standards for people, so there is no way to be sure of their strength, purity or sterility, or how well they will work.
| Prescribed and pharmacy-compounded at Padgett | Research-grade / research use only |
|---|---|
| Who decides it's right for you | |
| A licensed provider reviews your health history at a free consultation before anything is prescribed. | No one. You pick a vial from a website. |
| Where it's made | |
| A licensed U.S. compounding pharmacy, made for you to a prescription. | Unknown manufacturers, often overseas, selling "for research use only". |
| Meant for people? | |
| Yes. Compounded for a named patient to take. | No. Labeled not for human use or consumption. |
| Strength, purity and sterility | |
| Held to pharmacy compounding standards. | Not verified to pharmacy standards, so the dose and what else is in the vial are unknown. |
| Support while you take it | |
| Tell your provider about any side effect or question while you take it; they can adjust your plan. | You're on your own. |
| Price | |
| Published on every peptide page, and the consultation is free. | Cheap per vial, but you can't know what you're paying for. |
Regulatory status
Are these peptides FDA-approved? Where things stand in November 2026
No. BPC-157, TB-500, KPV, MOTS-c, Semax and Epitalon are not FDA-approved, and compounded medications are not FDA-approved. The FDA does not review compounded drugs for safety, effectiveness or quality before they are prescribed.
On October 30, 2026, the U.S. Department of Health and Human Services (HHS) published a notice in the Federal Register about an interim policy for compounding these six peptides. It says HHS does not intend to take enforcement action against state-licensed pharmacies and licensed physicians that compound them for individual patients while the FDA completes formal rulemaking, as long as specific conditions are met. Those conditions include:
- A prescription for each patient
- A bulk ingredient from an FDA-registered manufacturer, tested for identity, purity, strength and contaminants
- One peptide per product, so no blends
- Only the forms the policy lists for each peptide (for example, Semax only as a nasal spray)
- For forms taken by mouth, documentation that enough of the peptide is absorbed in people
- Reporting serious side effects to the FDA
The policy is temporary and may change. The Federal Register notice announced it as a draft, open for public comment into mid-November 2026, so HHS may revise it, and HHS has said it may revisit it if safety or quality problems come up. The policy does not mean these peptides are proven safe or effective. It does not cover peptides sold as research chemicals or supplements.
Before it, in July 2026, an FDA advisory committee voted to recommend adding these six peptides to the list of substances pharmacies may compound from. FDA staff had recommended against it, citing limited human safety data, and the vote is advisory.
At Padgett Medical Center, peptides are prescribed only after a consultation with a licensed provider, and each one is compounded for you by a licensed U.S. compounding pharmacy.
Sources: Federal Register: notice of the HHS interim policy on 503A compounding of certain peptides, 91 FR 68526 (October 30, 2026), FR Doc. 2026-22192; Holland & Knight: HHS issues interim enforcement discretion policy for compounding of 6 peptides (November 4, 2026); FDA: Certain bulk drug substances for use in compounding that may present significant safety risks (content current April 22, 2026); Healio: FDA committee recommends looser restrictions for several peptides (July 24, 2026).
MOTS-c questions, answered
What is MOTS-c?
MOTS-c is a small peptide your body makes naturally. Its code is stored in the DNA of your mitochondria, the energy-producing parts of your cells. The prescribed form is a lab-made copy given as a small injection under the skin. It is sometimes called an exercise mimetic because, in mice, it switched on some of the same energy pathways exercise does. Any benefit would add to regular activity, not replace it.
Has MOTS-c been tested in people?
Very little. Most human studies measure the MOTS-c your body already makes, for example how it rises after exercise. A modified version finished an early safety trial in 2021, but its results have not been published in a medical journal. In 2026, FDA reported that it found no published clinical studies of MOTS-c given to people. Its possible benefits in humans are not yet established.
Will MOTS-c help me lose weight?
This has not been shown in people. In mice on a high-fat diet, MOTS-c reduced weight gain and insulin resistance, but no human trial has tested MOTS-c for weight loss, and Padgett does not offer it as a weight-loss treatment. If weight loss is your main goal, a provider can go over all of your medical weight loss options.
I have diabetes or prediabetes. Can I take MOTS-c?
Possibly, but only with care. MOTS-c may lower blood sugar, so it could add to the effect of insulin, sulfonylureas, metformin or GLP-1 medicines like semaglutide or tirzepatide. Your provider reviews your medicines first, and you may need to check your blood sugar more often. Know the signs of low blood sugar: shakiness, sweating, a fast heartbeat, hunger and confusion.
What side effects can MOTS-c cause?
Reported or expected side effects include nausea, headache, tiredness, dizziness, anxiety, trouble sleeping, redness or soreness where you inject, and low blood sugar. Like any injected peptide, it can cause allergic reactions. Long-term effects are not known, because no long-term human studies exist. MOTS-c is also prohibited for drug-tested athletes under World Anti-Doping Agency rules.
Is MOTS-c FDA-approved?
No. MOTS-c is not an FDA-approved drug, and compounded peptides are not FDA-approved. At Padgett it is prescribed only after a consultation with a licensed provider, and it is compounded for the individual patient by a licensed U.S. compounding pharmacy. FDA has noted that human safety data for MOTS-c are limited.
Is MOTS-c legal in Florida?
MOTS-c is not FDA-approved, so the answer depends on how it is made and prescribed. On October 30, 2026, the U.S. Department of Health and Human Services (HHS) published a notice in the Federal Register about an interim policy for MOTS-c and five other peptides. It says HHS does not intend to take enforcement action against state-licensed pharmacies and licensed physicians that compound them for individual patients while the FDA completes formal rulemaking, as long as conditions are met, including a prescription for each patient, a tested ingredient from an FDA-registered manufacturer and one peptide per product. For MOTS-c, the policy covers only injections under the skin or into a muscle. The policy does not cover products sold online as "research use only". It is temporary and may change, and Florida pharmacy and medical rules still apply. At Padgett Medical Center, MOTS-c is prescribed after a consultation with a licensed provider and compounded by a licensed U.S. compounding pharmacy.
Where can I get MOTS-c in Tampa?
At Padgett Medical Center, 6904 W. Linebaugh Ave, Tampa, FL 33625. You start with a free consultation with a licensed provider, in person at our Tampa clinic or by telehealth from anywhere in Florida. If MOTS-c is right for you, a licensed U.S. compounding pharmacy compounds it for you, and you only pay for it if you start.
How is Padgett's MOTS-c different from "research grade" MOTS-c sold online?
"Research grade" or "research use only" MOTS-c is labeled not for human use. It is not made or checked to pharmacy standards for people, so its strength, purity and sterility are unknown. FDA has said that clumping and impurities in injected peptides raise the risk of immune reactions, which is why product quality and sterility matter. At Padgett, MOTS-c is prescribed only after a consultation with a licensed provider, and a licensed U.S. compounding pharmacy compounds it for you. Research-grade vs pharmacy-compounded peptides explains the difference.
How much does MOTS-c cost?
The consultation is free, and nothing is charged when you book. You only pay for MOTS-c if you start it. MOTS-c at Padgett Medical Center in Tampa costs $400 (injection, 10 mg in a 2 mL vial, 4 vials). New patients who book online with a card on file get 10% off their first peptide order ($400 becomes $360). Nothing is charged when you book, and current patients pay the listed price.
Other peptides we offer
Each is prescribed after the same free consultation. You can ask about more than one.
- Recovery and healingBPC-157Also called Body Protection Compound-157, BPC 157May support healing of tendons, ligaments and injuries, and the gut lining.From $275BPC-157 in Tampa
- Recovery and healingTB-500Also called Thymosin Beta-4 fragment, TB500May support tissue repair, wound healing and muscle recovery.From $300TB-500 in Tampa
- Gut health and inflammationKPVAlso called Lysine-Proline-Valine, KPV peptideMay calm gut and skin inflammation and support the intestinal barrier.From $90KPV in Tampa
- Focus and cognitionSemaxAlso called Semax nasal spray, Semax peptideMay support focus, memory and mental clarity, and ease brain fog.From $125Semax in Tampa
- Sleep and healthy agingEpitalonAlso called Epithalon, EpitaloneMay support sleep quality and healthy cellular aging.From $250Epitalon in Tampa
Peptide guides
MOTS-c and peptide therapy near you
Sources
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 2015 (PMC4350682)
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 2021 (PMC7817689)
- Kong BS, Lee C, Cho YM. Mitochondrial-encoded peptide MOTS-c, diabetes, and aging-related diseases. Diabetes & Metabolism Journal, 2023 (PMC10244198)
- FDA briefing document: MOTS-c-related bulk drug substances, Pharmacy Compounding Advisory Committee, July 23-24, 2026
- ClinicalTrials.gov NCT03998514: phase 1a/1b study of CB4211, a MOTS-c analog
- DLA Piper: FDA AdComm recommends adding six peptides to bulk list (July 2026)
- Federal Register: notice of the HHS interim policy on 503A compounding of certain peptides, 91 FR 68526 (October 30, 2026), FR Doc. 2026-22192
Free peptide consultation
Talk with a licensed provider about MOTS-c
The consultation is free. You only pay for your peptides if you start. In person at our Tampa clinic or by telehealth anywhere in Florida, and new patients who book online with a card on file get 10% off their first peptide order.
Interested in more than one peptide? Pick them all when you book.
* Compounded peptides have not been approved by the FDA. They have not been reviewed by the FDA for safety, effectiveness or quality, and none of the peptides on this site is an FDA-approved drug. The benefits described are possibilities from research, not promises, and results vary from person to person. A licensed provider decides at your consultation whether a peptide is right for you. This page is educational and is not medical advice.
